#  Henderson Prize 

 



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###  **Lawrence J. Henderson Prize**

 The Henderson Prize honors the work of Professor Henderson (1878-1942), who began teaching at Harvard in 1905 and is best known for his research on blood biochemistry. The prize consists of a $500 book award, a framed certificate, and a copy of Dr. Henderson's book, "Fitness of the Environment." Each year a committee of the Board of Tutors in Biochemical Sciences reviews all theses that have been evaluated as outstanding (A) by both thesis readers. One (and occasionally two) students are awarded the Henderson Prize annually.

##  Henderson Prize Recipients: 

 **2017 Henry Cousins** A Wnt-Dependent Model of Synaptic Organization in the Outer Retina **2016 Philip Cody He** Elucidating Mechanisms of Histone Methylation with a RNA Polymerase-Tethered Histone Lysine Methyltransferase **2015 Alexandra ****R**ojek**** A Regulatory Model of Heat Shock by Protein Assembly **2014 Ian Boothby** Structural Patterns of Synaptic Competition in the Motor Neuron Circuit **2013 **James Meixiong****  
The critical role of host lipid metabolism in determining the infectivity of Hepatitis C virus **2012 **Stephanie Lin****  
Integration of the ER and oxidative stress responses through SKN-1 **2012 ****Priscilla Wang******  
Netrin-1 Promotes Glioblastoma Invasion and Angiogenesis Through a Cathepsin B-Dependent Mechanism **2011 Siyuan (John) Liu and Yunsoo Kim**  
John’s thesis title is “Single Cell Temporal Dynamics and Spatial Reorganization of Oct4 in Mouse Embryonic Stem Cells Reveal Differential Activation of the Pluripotency Circuit During Cell Fate Selection”  
Yunsoo’s thesis title is “A conserved cytoplasmic tyrosine kinase functions in the transport of silencing RNA between C. elegans cells” **2010 Daniel Bear and Laura Huppert**  
Dan’s thesis title is “Genome-wide and Single-cell Analysis of Neuronal Activity-regulated Gene Expression”  
Laura’s thesis title is “Localization, Regulation, and Function of a First Type VII Protein Secretion System in Bacillus subtilis” **2009 Kaloyan Tsanov**   
An Embryonic Stem Cell Based System for Rapid Analysis of Developmentally Regulated Enhancer Elements **2008 Katie Rose Clapham**   
A Tiny Protein Links Two Morphogenetic Processes in a Bacterium **2007 Alisa Anne Mueller**   
I. Structural and Mechanistic Studies of TadA, an Adenosine Deaminase that Acts on tRNA  
II. Structural and Biochemical Analysis of the C-terminal Domain of UvrC, a DNA Damage Repair Enzyme **2006 Milena Maria Andzelm**   
The Role of Myosin II in Natural Killer Cell Effector Function **2006 Shelly SeungAh Choo**   
Structural and Biochemical Studies of the N-Terminal Region of the Temperature-Sensing TRPV Ion Channels **2005 Sarah J. Hill**   
Characterization of a Novel Chromodomain Protein **2004 Rozalina Grubina**   
The Development of DNA-Templated Synthesis for the Creation and Discovery of Synthetic Small Molecules **2003 John Christian Huetsch**   
Crystal Structure of the DNA-wrapping Domain of DNA Gyrase A from *Escherichia coli* **2002 Narie J. Yoo**   
The Identification of Genes Involved in the Development of *Streptomyces coelicolor*. **2001 Jeffrey Lu**   
Characterization of Deletions Created by the Hybrid Mobile Element P {why}to Study Gene Function in *Drosophilia Melanogaster*. **2000 Ryan Edward Dorris**   
Tumor Cell Lines Resistant to Caspase-Mediated Apoptosis Are Sensitive to CTL Attack, Granzyme Loading, and UV Irradiation. **2000 James L. Young**   
The Serpin PI-9 is an Endogenous Inhibitor of Interleukin-1b-Converting Enzyme (Caspase-1) Activity in Human Vascular Smooth Muscle Cells. **1999 Timothy Yu-Ting Tseng**   
Biochemical Characterization of the *Salmonella typhimurium* Phage SP6 DNA Primase **1998 Aurelio A. Teleman**   
Studies on the Segregation and Architecture of the Bacterial Chromosome. **1997 Joshua Shulman**   
A Genetic Analysis of Drosophila Dishevelled Reveals Distinct Roles in Planar Polarity Specificati and Wingless Signal Transduction. **1996 Jeffrey Tong**   
Catalytic Mechanism of Fpg. **1995 Carl Aschkenasi**   
Isolation and Characterization of Six Drosophila Lines Mutant in the formation of the Retinotopic Map. **1995 Oliver Rando**   
Elucidation of the Mechanism of Activation of Nf- B: the Proteasome is Required for Processing of the 105Kd Nf- B1 Precursor and Degradation of I- B. **1994 Rojat Rohatgi**   
Non-emzymatic Template-directed Ligation Reactions of Ribo-oligonucleotides. **1993 Dan Barouch**   
Role of the Minor Coat Protein Vp3 in the Structural Organization of the Polyomavirus Capsid. **1993 Bernard Chang**   
The Functional Significance of the Cd4-T Cell Receptor Interaction. **1992 Andre Cheng**   
Does Haploinsufficiency of the Drosophila Ribosomal Protein Gene Rps4 Result in the Minute Phenotype? **1992 Ted Mau**   
Structure and Dynamics in Protein-dna Interaction: A Nuclear Magnetic Resonance Study of Gal4. **1991** **Kathleen D. Liu**  
Structure Function Relationships of Triosephosphate Isomerase. **1990** **Jayaraj Rajagopal**   
The Structure and Enzymatic Activity of the Tetrahymena Ribozyme. **1989 Paul A. Monach**  
Identification of a Putative Regulatory Gene for Defense Against Oxidative Damage in Escherichia Coli. **1988 Lucy Ann Godley**   
The Mutagenesis, Expression, and Characterization of Two Hemagglutinin Mutants. **1988 theodore S. Steiner**   
Voltage Clamp Studies of the Excitatory Response To Capsaicin in Pain Neurons. **1987** **Calvin J. Kuo**   
Purification, Characterization and Modes of Activation of A Putative Growth- and Transformation-sensitive Ribosomal Protein S6 Kinase. **1986 Julie Nardone**   
Characterization of a Bradykinin Receptor by Binding of 3H-bradykinin. **1985** **Seung K. Kim**   
Pp4 Virl Master Copy: A Novel Mechanism for Plasmid Establishment and Maintenance. **1984 Calvin Ho**  
Point Mutations in a Aminoterminal Fragment of Alanine Transfer Rna Synthetase Which Elevate Activity. **1984 Peter Sorger**   
The Self-assembly of Turnip Crinkle Virus, an Icosaherdral Rna Virus. **1983 Charles Cassidy**   
Modulatory Role for the Cholinergic Amacrine: Two Types of Acetylcholine Release in the Rabbit Retina. **1983 Albert C. Shaw**  
Sequence Dependence of the Helical Repeat of Dna in Solution. **1982 Judith Bender**  
Physical and Functional Properties of Brain Adenylate Cylase Catalytic Component. **1981 Se-Jin Lee**  
Altered Patterns of Gene Expression by Satellite P4 Mutants Unable to Regulate their P2 Helper. **1981 Juliann M. Paolicchi**   
Characterization of an Induction Sensitive Mutation in Bacteriophage Lambda. **1980** **Christopher A. Kaiser**  
The Role of Lambda Dna Replication in the Transposition of Tn5. **1979 Thanh Van Huynh**   
A Walk Along the Bacillus Subtilis Chromosome in a Region Containing Developmentally-controlled Genes. **1979 Seth Jay Orlow**   
The Extracellular Cyclic Amp Phosphodiesterase of Dictyostelium Discoideum and its Interaction with its Inhibitor. **1978 Charles L. Diana**   
Studies on A Multigenomic Bacteriophage. **1978 Marcia M. Moore**   
An Investigation of the Metabolism of Tyrosine and Tyramine in the Central Nervous System of the Moth Manduca Sexta. **1977** **David M. Shore**  
Head Size Determination of Icosahedral Viruses, the Isolation and Characterization of Satellite Bacteriophage P4 Mutant Affected in Head Size Determination. **1976 Dorothy Jessel**   
Studies on the Dna Binding of Sv40 T Antigen. **1975** **Nicholas Cataldo**   
Studies on the Mechanism of Action of a Phospodiesterase. **1975 Stephen Rayport**   
Frog Skin Photoreceptors. **1974 Daniel Podolsky**  
Concanavalin A Agglutination. **Honorable Mention: Donald Kennerly**   
Idiotypic Analysis of Antibodies Present During the 37 Week Immune Response of a Single Rabbit. **1973 Perrin Charles**   
Molecular Mechanism of Nonspecific Permeation Through Lipid Membranes. **Honorable Mention: Jane Robin Parnes**   
Energy Coupling in the B-methylgalactoside Transport System of Escherichia Coli. **1971 Heng Soon Tan**   
Studies in the Binding of Neurophysin to Vasopressin.  [to top](#top)