#  One brain, many genomes: genomic variability between single neurons in health and disease 

 



####  calendar\_today Date and Time 

 **September 30, 2014** 

 06:15PM - 06:15PM EDT 

####  pin\_drop Location 

 **BioLabs 1080, 16 Divinity Avenue, Cambridge, MA 02138**  



 

 



 

Christopher A. Walsh, M.D., Ph.D.  
Chief, Division of Genetics and Genomics, Children's Hospital Boston  
Investigator, Howard Hughes Medical Institute  
Bullard Professor, Pediatrics and Neurology, Harvard Medical School

Tuesday September 30th at 6:30PM  
Light refreshments served at 6:15PM  
The Biological Labs, Room 1080  
16 Divinity Avenue, Cambridge

As soon as the fertilized egg divides for the first time, the genomes of cells start accumulating spontaneous mutations, due to errors in DNA replication or other causes. In principle, every cell in the body has its own distinct genome defined by spontaneous mutations. Though the role of spontaneous, clonal mutations in cancer is well known, more recently some brain diseases have been found to reflect similar types of mutations, while genomic variability has been suggested to have potential roles in normal brain as well.

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